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mono drug resistant strains isoniazid resistant h37rv  (ATCC)


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    ATCC mono drug resistant strains isoniazid resistant h37rv
    MICs of Homo-BacPROTACs and monomers against clinical isolates resistant to single Mtb drugs
    Mono Drug Resistant Strains Isoniazid Resistant H37rv, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/isoniazid+resistant+strain/Mycobacterium+tuberculosis/pmc10914731-323-13-23
    Average 94 stars, based on 28 article reviews
    mono drug resistant strains isoniazid resistant h37rv - by Bioz Stars, 2026-08
    94/100 stars

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    1) Product Images from "Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria"

    Article Title: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

    Journal: Nature Communications

    doi: 10.1038/s41467-024-46218-7

    MICs of Homo-BacPROTACs and monomers against clinical isolates resistant to single Mtb drugs
    Figure Legend Snippet: MICs of Homo-BacPROTACs and monomers against clinical isolates resistant to single Mtb drugs

    Techniques Used:

    a , b Exit vector 6-based Homo-BacPROTACs 7 and 8 (UdSBI-0545), as well as exit vector 7-based Homo-BacPROTACs 11 and 12 (UdSBI-4377) were assessed in a 4- and 7-day incubation on THP-1 macrophages following infection with Mtb H37Rv. The Homo-BacPROTACs were compared to their corresponding monomers ( 5 for exit vector 6 and 10 for exit vector 7) and the reference antibiotics rifampicin and moxifloxacin, which are known to inhibit the intracellular propagation of Mtb H37Rv. Exit vector 6 Homo-BacPROTACs showed a more efficient concentration-dependent reduction of cfu/ml over time with an E max of 1.22 − 1.27 at 50 µM, as compared to exit vector 7 based Homo-BacPROTACs or matched monomers. The various compound concentrations are indicated in different colours, matching across the panels. CC means Mtb culture control, where no drug treatment was given. For further details see text. Error bars indicate mean ± SD of n = 2 well replicates. The CC, rifampicin and moxifloxacin values were taken as common reference points in the various graphs. Source data are provided as a Source Data file.
    Figure Legend Snippet: a , b Exit vector 6-based Homo-BacPROTACs 7 and 8 (UdSBI-0545), as well as exit vector 7-based Homo-BacPROTACs 11 and 12 (UdSBI-4377) were assessed in a 4- and 7-day incubation on THP-1 macrophages following infection with Mtb H37Rv. The Homo-BacPROTACs were compared to their corresponding monomers ( 5 for exit vector 6 and 10 for exit vector 7) and the reference antibiotics rifampicin and moxifloxacin, which are known to inhibit the intracellular propagation of Mtb H37Rv. Exit vector 6 Homo-BacPROTACs showed a more efficient concentration-dependent reduction of cfu/ml over time with an E max of 1.22 − 1.27 at 50 µM, as compared to exit vector 7 based Homo-BacPROTACs or matched monomers. The various compound concentrations are indicated in different colours, matching across the panels. CC means Mtb culture control, where no drug treatment was given. For further details see text. Error bars indicate mean ± SD of n = 2 well replicates. The CC, rifampicin and moxifloxacin values were taken as common reference points in the various graphs. Source data are provided as a Source Data file.

    Techniques Used: Plasmid Preparation, Incubation, Infection, Concentration Assay, Control

    Structure-activity relationships of monomeric dCym derivatives and Homo-BacPROTACs
    Figure Legend Snippet: Structure-activity relationships of monomeric dCym derivatives and Homo-BacPROTACs

    Techniques Used: Permeability



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    MICs of Homo-BacPROTACs and monomers against clinical isolates resistant to single Mtb drugs

    Journal: Nature Communications

    Article Title: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

    doi: 10.1038/s41467-024-46218-7

    Figure Lengend Snippet: MICs of Homo-BacPROTACs and monomers against clinical isolates resistant to single Mtb drugs

    Article Snippet: The different Mtb strains used were drug-sensitive strains (H37Rv ATCC 27294 and 11291), mono drug resistant strains Isoniazid resistant H37Rv (katG del ) ATCC 35822 , Rifampicin resistant H37Rv (rpoB S450L ) ATCC 35838 , moxifloxacin resistant H37Rv clinical isolate FNDR-M1 as well as multidrug resistant strains (ATCC 35825 and 8673) with drug-resistance against 1st and 2nd-line anti-TB drugs.

    Techniques:

    a , b Exit vector 6-based Homo-BacPROTACs 7 and 8 (UdSBI-0545), as well as exit vector 7-based Homo-BacPROTACs 11 and 12 (UdSBI-4377) were assessed in a 4- and 7-day incubation on THP-1 macrophages following infection with Mtb H37Rv. The Homo-BacPROTACs were compared to their corresponding monomers ( 5 for exit vector 6 and 10 for exit vector 7) and the reference antibiotics rifampicin and moxifloxacin, which are known to inhibit the intracellular propagation of Mtb H37Rv. Exit vector 6 Homo-BacPROTACs showed a more efficient concentration-dependent reduction of cfu/ml over time with an E max of 1.22 − 1.27 at 50 µM, as compared to exit vector 7 based Homo-BacPROTACs or matched monomers. The various compound concentrations are indicated in different colours, matching across the panels. CC means Mtb culture control, where no drug treatment was given. For further details see text. Error bars indicate mean ± SD of n = 2 well replicates. The CC, rifampicin and moxifloxacin values were taken as common reference points in the various graphs. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

    doi: 10.1038/s41467-024-46218-7

    Figure Lengend Snippet: a , b Exit vector 6-based Homo-BacPROTACs 7 and 8 (UdSBI-0545), as well as exit vector 7-based Homo-BacPROTACs 11 and 12 (UdSBI-4377) were assessed in a 4- and 7-day incubation on THP-1 macrophages following infection with Mtb H37Rv. The Homo-BacPROTACs were compared to their corresponding monomers ( 5 for exit vector 6 and 10 for exit vector 7) and the reference antibiotics rifampicin and moxifloxacin, which are known to inhibit the intracellular propagation of Mtb H37Rv. Exit vector 6 Homo-BacPROTACs showed a more efficient concentration-dependent reduction of cfu/ml over time with an E max of 1.22 − 1.27 at 50 µM, as compared to exit vector 7 based Homo-BacPROTACs or matched monomers. The various compound concentrations are indicated in different colours, matching across the panels. CC means Mtb culture control, where no drug treatment was given. For further details see text. Error bars indicate mean ± SD of n = 2 well replicates. The CC, rifampicin and moxifloxacin values were taken as common reference points in the various graphs. Source data are provided as a Source Data file.

    Article Snippet: The different Mtb strains used were drug-sensitive strains (H37Rv ATCC 27294 and 11291), mono drug resistant strains Isoniazid resistant H37Rv (katG del ) ATCC 35822 , Rifampicin resistant H37Rv (rpoB S450L ) ATCC 35838 , moxifloxacin resistant H37Rv clinical isolate FNDR-M1 as well as multidrug resistant strains (ATCC 35825 and 8673) with drug-resistance against 1st and 2nd-line anti-TB drugs.

    Techniques: Plasmid Preparation, Incubation, Infection, Concentration Assay, Control

    Structure-activity relationships of monomeric dCym derivatives and Homo-BacPROTACs

    Journal: Nature Communications

    Article Title: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

    doi: 10.1038/s41467-024-46218-7

    Figure Lengend Snippet: Structure-activity relationships of monomeric dCym derivatives and Homo-BacPROTACs

    Article Snippet: The different Mtb strains used were drug-sensitive strains (H37Rv ATCC 27294 and 11291), mono drug resistant strains Isoniazid resistant H37Rv (katG del ) ATCC 35822 , Rifampicin resistant H37Rv (rpoB S450L ) ATCC 35838 , moxifloxacin resistant H37Rv clinical isolate FNDR-M1 as well as multidrug resistant strains (ATCC 35825 and 8673) with drug-resistance against 1st and 2nd-line anti-TB drugs.

    Techniques: Permeability

    Multiple logistics regression analysis of determinants for MDR-TB in Addis Ababa, Ethiopia, between April 2013 and June 2013

    Journal: Infection and Drug Resistance

    Article Title: Determinants of multidrug-resistant tuberculosis in Addis Ababa, Ethiopia

    doi: 10.2147/IDR.S134369

    Figure Lengend Snippet: Multiple logistics regression analysis of determinants for MDR-TB in Addis Ababa, Ethiopia, between April 2013 and June 2013

    Article Snippet: Treatment of MDR-TB ( Mycobacterium tuberculosis strains resistant to at least isoniazid and rifampicin [Sigma-Aldrich Co., St Louis, MO, USA]) is very complex.

    Techniques: